1. Taw qhia
Yog tias koj ua raws li kev lag luam thoob ntiaj teb cov khoom xyaw kom zoo nkauj, koj tau tuaj hla lub npeSH-Oligopeptide-1.Cov neeg muag khoom hauv Tebchaws Europe thiab Asmeskas ua lag luam nws yog qhov zoo tshaj los tiv thaiv- kev laus ua haujlwm, thov nws txhawb kev tsim kho ntawm tes, kho cov tawv nqaij barrier, thiab txo cov wrinkles. Tab sis thaum koj tshawb xyuas nws tawm tsam Tuam Tshoj cov khoom xyaw tshuaj pleev ib ce, nws sai sai pom tseeb tias cov khoom xyaw no tsis zoo ib yam li "Oligopeptide-1" tso cai los ntawm Suav cov cai.
Cov ntaub ntawv sib txawv no tau ua rau ntau tus neeg yuav khoom nkag mus rau hauv cov cuab yeej.
Raws li thoob ntiaj teb INCI naming system, SH-Oligopeptide-1 yog hais txog recombinant human epidermal growth factor (EGF), bioactive peptide ua los ntawm 53 amino acids nrog ib qho hnyav molecular txog 6200 Da. Nws cov txheej txheem tau nkag siab zoo: nws khi rau lub epidermal kev loj hlob zoo tshaj plaws receptor, activates downstream signaling pathways, thiab txhawb kev loj hlob, sib txawv, thiab tsiv teb tsaws ntawm epidermal hlwb thiab fibroblasts. Hauv kev kho mob, EGF yog siv los txhawb kev kho cov qhov txhab nyuaj. Hauv kev lag luam tshuaj pleev ib ce, nws tau pom ib zaug los ua cov khoom siv hnub qub rau kev kho thiab tiv thaiv kev laus.
Tab sis nyob rau hauv Suav teb, qhov xwm txheej txawv kiag li. Hauv 2019, National Medical Products Administration (NMPA) tau hais meej meej tias tib neeg oligopeptide-1 (EGF) tsis tuaj yeem siv los ua cov khoom siv tshuaj pleev ib ce. "Oligopeptide-1" tso cai nyob rau hauv Suav txoj cai yog ib qho hluavtaws tripeptide ua los ntawm glycine, histidine, thiab lysine (GHK), nrog rau qhov hnyav molecular txog 340 Da - ib yam khoom sib txawv kiag li.
Lub ntiaj teb no recombinant EGF lag luam tseem loj hlob. Ib daim ntawv tshaj tawm kwv yees tias lub ntiaj teb recombinant tib neeg EGF kev lag luam yog kwv yees li $ 820 lab hauv 2023 thiab xav tias yuav ncav cuag $ 1.25 nphom los ntawm 2030. Tshuaj pleev ib ce thiab kev tu tawv nqaij yog qhov tseem ceeb ntawm daim ntawv thov. Txawm li cas los xij, vim muaj kev txwv tsis pub muaj nyob hauv Suav teb, qhov kev thov no tsuas yog tuaj yeem ua tau los ntawm kev hla - ciam teb e- kev lag luam lossis kev lag luam xa tawm.
2. Qhov tseeb yog dab tsiSH-Oligopeptide-1?
SH-Oligopeptide-1 tau txais nws lub npe los ntawm INCI (International Nomenclature of Cosmetic Ingredients) system. Chemically, nws yog recombinant tib neeg epidermal loj hlob zoo tshaj plaws, tsim los ntawm noob caj noob ces engineering (feem ntau siv E. coli los yog poov xab qhia systems), nrog rau cov amino acid ib ntus zoo ib yam rau tib neeg EGF.
Nws qhov hnyav molecular yog li 6200 Da, muaj 53 amino acids nrog peb disulfide bonds uas tsim ib tug ruaj khov peb -dimensional qauv. Cov qauv no txiav txim siab nws cov bioactivity - nws tshwj xeeb khi rau EGFR ntawm cov cell membranes thiab ua rau muaj kev cuam tshuam ntawm cell proliferation thiab migration signals.
Muab piv rau cov peptides me me uas feem ntau siv hauv cov tshuaj pleev ib ce (xws li GHK, palmitoyl pentapeptide, thiab lwm yam), SH-Oligopeptide-1 yog qhov loj dua thiab nws cov txheej txheem yog ntau dua li ntawm "cov teeb liab molecule" ntau dua li "cov khoom tiv thaiv." Nws tsis ncaj qha muab collagen tsev blocks; Hloov chaw, nws qhia cov hlwb los tsim collagen ntau dua, hyaluronic acid, thiab elastic fibers.
Hauv kev sib piv, "Oligopeptide-1" hauv Suav txoj cai yog ib yam khoom sib txawv. Raws li NMPA cov lus piav qhia, Oligopeptide-1 yog peptide hluavtaws muaj li ntawm glycine, histidine, thiab lysine, nrog rau qhov hnyav molecular txog 340 Da. Ob qho tib si sib txawv hauv qhov chaw, qauv, qhov hnyav molecular, thiab kev tswj hwm.
| Kev sib piv | SH-Oligopeptide-1 | Tshuaj pleev ib ce "Oligopeptide-1" (Tuam Tshoj) |
| Qhov chaw | Recombinant DNA technology (E. coli / poov xab) | Tshuaj synthesis |
| Tus naj npawb ntawm cov amino acids | 53 | 3 |
| Molecular hnyav | ~ 6200 Nws | ~ 340 Nws |
| Mechanism | EGFR receptor agonist | Hlau ion complexation, signaling tswj |
| Tuam Tshoj kev cai tshuaj pleev ib ce | Txwv tsis pub | Teev nyob rau hauv cov khoom siv catalog |
Ntau tus neeg muag khoom txawv teb chaws muag SH-Oligopeptide-1 ncaj qha raws li "EGF" lossis "recombinant human EGF," uas yog ua raws li European thiab Asmeskas kev lag luam. Tab sis thaum imported rau hauv Suav teb rau kev tsim tshuaj pleev ib ce, nws khiav mus rau hauv cov kev cai txwv.
3. Cov ntaub ntawv ua tau zoo – Yuav ua li casSH-Oligopeptide-1Ua tiag?
Kev tshawb fawb ntawm SH-Oligopeptide-1 tau tsom mus rau kev kho daim tawv nqaij thiab tiv thaiv kev laus, nrog cov ntaub ntawv zoo hauv vitro thiab cov ntaub ntawv kho mob.
Epidermal kho thiab kho qhov txhab.Qhov no yog thaj chaw validated ntxov tshaj plaws rau EGF. Ntau cov kev tshawb fawb tau pom tias exogenous EGF accelerates kev tsiv teb tsaws ntawm keratinocytes thiab fibroblasts, txo cov tawv nqaij teeb meem kho lub sij hawm. Hauv kev tshaj tawm -laser, post- tshuaj tev, lossis kho qhov khawb qhov muag, EGF- muaj cov qauv ua kom rov ua dua- epithelialization thiab txo cov post- mob hyperpigmentation. Hauv ib qho kev sim tshuaj, lub sijhawm kho mob hauv EGF gel pawg tau luv luv li ntawm 30% piv rau pawg tswj hwm.
Los tiv thaiv -aging thiab wrinkle txo.EGF txhawb nqa hom I thiab hom III collagen synthesis hauv dermal fibroblasts, ua kom tawv nqaij tuab thiab elasticity. Hauv 8-lub lim tiam randomized tswj kev sim, ib qho EGF- muaj cov qab zib kom txo qis qhov tob li ntawm 20% thiab txhim kho daim tawv nqaij firmness. Txawm li cas los xij, feem ntau ntawm cov kev tshawb fawb no tau siv kev nkag mus rau -txoj kev txhim kho (microneedling, liposomes, cell-peptides) vim EGF qhov hnyav molecular hnyav ua rau nws nyuaj rau nkag mus rau cov tawv nqaij noj qab haus huv ntawm nws tus kheej.
Lwm thaj chaw.Qee qhov kev tshawb fawb tau tshawb xyuas EGF lub peev xwm hauv kev tiv thaiv UV, tiv thaiv -mob, thiab kev loj hlob ntawm cov plaub hau, tab sis cov pov thawj tsis muaj zog dua li kho thiab tiv thaiv- kev laus.
Daim ntawv tseem ceeb:EGF qhov ua tau zoo yog nyob ntawm qhov ncaj ncees ntawm nws peb - qauv qauv. Txhua yam uas rhuav tshem cov nyiaj disulfide lossis denatures cov protein (siab kub, muaj zog acids / bases, organic solvents, ntev stirring) yuav inactivate nws. Qhov no yog ib qho kev sib tw loj hauv kev tsim qauv.
4. Cov tswv yim muab kev lag luam sib txawv
Kev txiav txim siab rau qhov chaw SH-Oligopeptide-1 nyob ntawm koj lub hom phiaj kev muag khoom lag luam.
Muag tsuas yog nyob rau hauv Tuam Tshoj mainland:Tsis txhob kov nws. Tau qhov kev ua raws li "Oligopeptide-1" (GHK tripeptide) lossis "Copper Tripeptide-1 (GHK-Cu)" hloov. Lawv muaj cov ntaub ntawv muaj txiaj ntsig zoo thiab kev tswj hwm txoj cai.
Exporting rau European lossis Asmeskas kev lag luam:Koj tuaj yeem muab nws. Cov neeg tswj hwm European thiab Asmeskas tau ua siab ntev rau EGF. FDA kho nws raws li cov khoom siv tshuaj pleev ib ce uas tsis muaj kev pom zoo ua ntej -, tab sis cov tuam txhab muaj lub luag haujlwm rau kev nyab xeeb. Lub EU's EC 1223/2009 tsis txwv EGF, tab sis cov kev cai dav dav rau kev nyab xeeb ntawm cov tshuaj pleev ib ce. Thaum muab khoom, nug rau cov khoom siv tshwj xeeb -COA tshwj xeeb, cov ntawv tshaj tawm kev xeem purity, kuaj endotoxin (yuav tsum tau txhaj rau qib; xaiv tau rau qib tshuaj pleev ib ce), thiab tsis yog- tsiaj ntawv tshaj tawm.
Hla - ciam teb e- lag luam lossis hom lag luam txawv teb chaws OEM:Koj tuaj yeem muab nws, tab sis yuav tsum paub txog cov kev cai sib txawv hauv lub teb chaws qhov chaw. Qee lub tebchaws (xws li Canada, Australia) tau nruj kev saib xyuas ntawm EGF - xyuas ua ntej xa khoom.
5. Kev Tswj Xyuas Zoo - Yuav Ua Li Cas Los Ntawm COA
Thaum muab khoomSH-Oligopeptide-1 hmoov, COA yuav tsum tsawg kawg suav nrog cov kev txwv hauv qab no:
| Parameter | Hom Specification | Vim Li Cas Nws Tseem Ceeb |
| Qhov tshwm sim | Dawb rau tawm -dawb hmoov | Kev kuaj ceev |
| Purity (HPLC) | Ntau dua lossis sib npaug rau 95% - Ntau dua lossis sib npaug rau 98% | Core qhia; low purity txhais tau hais tias ua haujlwm tsis zoo |
| Molecular Luj (mas spec) | ~ 6200 Nws | Paub meej tias tag nrho -length EGF, tsis tawg |
| Bioactivity (kev ntsuam xyuas cell proliferation) | ED50 Tsawg dua lossis sib npaug li 1 ng / mL | Daim ntawv pov thawj ncaj qha ntawm kev ua haujlwm |
| Endotoxin | Tsawg dua lossis sib npaug li 10 EU / mg (qib tshuaj pleev ib ce tuaj yeem xoob) | nruj rau qib txhaj tshuaj; qib siab tseem pheej hmoo |
| Cov hlau hnyav (Pb, As, Hg, Cd) | Pb Tsawg dua lossis sib npaug 2, Raws li Tsawg dua lossis sib npaug rau 1, Hg Tsawg dua lossis sib npaug rau 0.1, Cd Tsawg dua lossis sib npaug rau 1 mg / kg | Kev nyab xeeb hauv paus |
| Microbiology | TPC Tsawg dua lossis sib npaug li 100 CFU / g; tsis muaj kab mob | Cov khoom siv roj ntsha muaj kev pheej hmoo siab dua |
| Residual kuab tshuaj | Hauv USP txwv | Fermentation / purification yuav siv acetic acid, acetonitrile |
Cov lus qhia ntxiv txog kev xa khoom:
Kev nthuav qhia system.E. coli systems raug nqi tsawg tab sis muaj kev pheej hmoo siab endotoxin; Cov kab mob poov xab muaj qis endotoxin tab sis raug nqi me ntsis ntxiv. Xaiv raws li qhov xav tau siv.
Xaiv daim ntawv.SH-Oligopeptide-1 hmoov yog ruaj khov dua li kev daws. Yuav cov hmoov thiab npaj cov khoom tshiab los yog ua cov khoom lyophilized thaum tsim.
Kev txheeb xyuas kev ruaj ntseg.Nug tus neeg muag khoom kom ceev cov ntaub ntawv ruaj ntseg (xws li, purity hloov tom qab 3 lub hlis ntawm 40℃/ 75% RH).
6. B2B FAQs
Q1: Puas yog SH-Oligopeptide-1 zoo ib yam li cov khoom xyaw tshuaj pleev ib ce "Oligopeptide-1" hauv Suav teb?
A: Tsis yog. SH-Oligopeptide-1 yog recombinant human EGF (53 amino acids). Tuam Tshoj tus "Oligopeptide-1" yog GHK tripeptide (3 amino acids). Lawv txawv ntawm cov qauv, qhov chaw, thiab kev tswj xyuas.
Q2: SH-Oligopeptide-1 puas tuaj yeem siv rau hauv cov tshuaj pleev ntsej muag uas tsim hauv Suav teb?
A: Tsis yog. NMPA tau txwv tsis pub tib neeg oligopeptide-1 (EGF) ua cov khoom siv tshuaj pleev ib ce. Kev siv nws yog txhaum cai thiab raug nplua.
Q3: Kuv yuav tsum saib dab tsi thaum muab SH-Oligopeptide-1 rau kev xa tawm?
A: Paub meej cov kev cai hauv koj lub lag luam phiaj xwm (EU, US, Southeast Asia, thiab lwm yam), nug tus neeg muag khoom kom ua tiav COA (purity, kev ua, endotoxin), thiab khaws cov ntaub ntawv khaws cia batch traceability. Tsis tas li ntawd, xyuam xim rau kev thauj khoom (txias saw, 2-8 degree).
Q4: Puas yog SH-Oligopeptide-1 ruaj khov hauv cov qauv?
A: Tsis ruaj khov heev. Nws yog rhiab heev rau cua sov, muaj zog acids / bases, thiab ntev stirring. Ntxiv nws hauv qab 40 degree, tsis txhob muaj cov chelators muaj zog, siv opaque ntim, thiab xav txog lyophilized los yog cais-chamber hom.
Q5: Vim li cas EGF raug txwv hauv Suav teb tab sis siv los ntawm ntau lub npe thoob ntiaj teb?
A: Vim tias cov qauv kev cai sib txawv. Cov neeg saib xyuas European thiab Asmeskas ntseeg tias cov pov thawj tam sim no tsis qhia txog kev nyab xeeb loj ntawm EGF hauv cov tshuaj pleev ib ce, yog li lawv tso cai. Tuam Tshoj siv txoj hauv kev ceev faj, hais txog qhov tsis txaus ntev - cov ntaub ntawv kev nyab xeeb raws li tsis yog - kho mob, siv tsis raug cai, thiab yog li txwv nws.
7. Xaus & Cov ntaub ntawv tiv tauj
SH-Oligopeptide-1 yog ib qho kev kawm zoo recombinant bioactive peptide nrog kev ua tau zoo thiab qhov chaw hauv kev lag luam tshuaj pleev ib ce thoob ntiaj teb. Txawm li cas los xij, nws txoj kev siv hauv Suav teb raug txwv nruj heev. Thawj txoj haujlwm rau cov neeg yuav khoom yog los txiav txim siab lub hom phiaj kev lag luam - rau kev muag khoom hauv Suav teb, zam nws tag nrho; rau kev xa tawm, qhov chaw ua raws li lub teb chaws txoj cai tswj hwm thiab siv tau cov qauv kev ruaj ntseg.
XI'AN LAND NUTRA CO., LTD. tam sim no tsis muab SH-Oligopeptide-1 (EGF). Txawm li cas los xij, peb tuaj yeem muab cov kev sib tham sib tham thiab pom zoo kom ua raws li kev hloov pauv rau cov neeg siv khoom xa tawm. Rau domestic-raws li "Oligopeptide-1" (GHK) lossis "Copper Tripeptide-1 (GHK-Cu)" raw cov ntaub ntawv, thov hu rau peb.
Tiv tauj peb rau:
Cov qauv dawb thiab COAs
Formulation kev txhim kho thiab kev ruaj ntseg kuaj kev txhawb nqa
Kev tswj cov ntaub ntawv kev pab rau European thiab Asmeskas kev lag luam
Txhawb me me -batch brand customization
Email:wangjing@landnutra.com
WhatsApp pawg: +86 18092657549
XI'AN LAND NUTRA- Pab koj kom tsis txhob muaj kev tswj hwm qhov teeb meem hauv kev tsim khoom thiab ua kom cov khoom ua raws li kev cai mus ntxiv.